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The aim of the project is to develop mass spectrometric methodologies
and protein separation techniques for the quantitative analysis of the entire
proteome of a single cell. Ultimately we will be studying angiogenesis in a
unique model system - consomic rat strains (chromosome substitution strains)
developed by the MCW PGA project. The technological
and experimental systems will be complemented by the use of bioinformatics to
store, process, integrate and explore this proteomic data in conjunction with
the phenotype, genotype and microarray data generated by the MCW PGA and other
public resources such as the Rat Genome Database.
This project has four main components:
| Components |
Role |
| 1. Proteomics & Technology Development |
Development of improved technologies
to extend the sensitivity, resolution and mass range of the analysis process. |
| 2. Animal
Models & Experimental Systems |
Development of the consomic rat models
that will ultimately provide model systems for the study of angiogenesis. |
| 3. Protein
Analysis & Technology implementation |
Development of protein separation techniques,
implementation of new MS technologies, analysis of consomic samples. |
| 4. Bioinformatics |
Data warehousing, implementation of
data analysis and data mining tools, development of novel algorithms and
databases in support of proteomic studies. |
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